Marge Theresa Lorang

6112 Syracuse Lane
San Diego, CA 92122-3301
(858) 587 – 9833

marge@spinosa.com

Education:

B.A. in BIOLOGY
University of California, San Diego

Employment History:

EDITORIAL COORDINATOR
Academic Press
Life and Biomedical Sciences Division

• Acquisition and development of medical and scientific book projects. Coordination of projects from idea stage through hand-off to Production Department. Worked with book editors and authors to discuss size, scope, and progress of book and electronic media products. Copy and substantive editing on selected projects. Meeting planning. Attendence at scientific symposia. Market research. Book sales at large national meetings.
• Book Projects:
  • Brain Mapping: The Systems, Toga, et. al.
  • Brain mapping: The Disorders. Mazziotta, et. al.
  • Alzheimer Disease: The Changing View, Katzman and Bick
  • Surgical Research, Souba and Wilmore
  • The Parathyroids, second edition, Bilezikian
  • Principles of Bone Biology, second edition, Bilezikian,et. al.
  • NKF Primer on Kidney Diseases, third edition, Greenberg, et. al.
  • MRI ATlas of the Human Cerebellum, Schmahmann, et. al.
• Editorial liason for journal editorial boards:
  • Journal of Surgical Research
  • NeuroImage

SENIOR RESEARCH ASSOCIATE
Neurocrine Biosciences
Department of Pharmacology

• Pharmacological characterization of cloned receptors, assay development for drug discovery and high-throughput screening, and pharmacokinetic analysis for mid-size biotech company. Design and management of several basic research collaborations. Technology development with outside manufacturers. Data processing, report writing, and presentations at internal company meetings, as well as national neuroscience conferences. Manuscript and SBIR grant preparation. Supervision and training of technicians.

RESEARCH ASSOCIATE
The Scripps Research Institute
Department of Neuropharmacology

• Academic neurochemistry research using animal models of drug addiction. Behavior, brain microdialysis and analytical chemistry. Lab manager. Coordinated research efforts of post-doctoral fellows, graduate students and technicians. Assisted with grant and manuscript preparation.

STAFF RESEARCH ASSOCIATE III
UCSD / VA Medical Center
Department of Psychiatry

• Neuroendocrine and CNS research. Animal models of depression and anxiety.

RESEARCH ASSOCIATE
UCSD / VA Medical Center
Endocrine Section, Department of Medicine

• Cell biology and biochemistry. Signal transduction research in bone and mineral metabolism.

TECHNICIAN
Salk Institute
Laboratories for Neuroendocrinology

• Reproductive endocrinology. Natural product isolation, RIA, tissue culture.

Relevant Coursework:

Publications:

1. 1. Grigoriadis DE, DeSouza EB, Duggan N, and Lorang MT. "CRF Receptors" (Unit 1.13) in Current Protocols in Pharmacology, edited by Enna S, et al. 1998. John Wiley & Sons, Publisher.
   2. Liaw CW, Grigoriadis DE, Lorang MT, DeSouza EB, and Maki RA. Localization of agonist and antagonist- binding domains of human corticotropin-releasing factor receptors. Molecular Endocrinology 11(13): 2048-2053, 1997.
   3. Heinrichs SC, Lapsansky J, Behan DP, Chan KW, Sawchenko PE, Lorang MT, Ling N, Vale WE, and DeSouza EB. Corticotropin-releasing factor binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal. Proceedings of the National Academy of Science 93(26): 15475-15480, 1996.
   4. Weiss F, Parsons LH, Schulteis G, Hyytia P, Lorang MT, Bloom FE, and Koob GF. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. Journal of Neuroscience 16(10): 3474-3485, 1996.
   5. Pich EM, Lorang MT, Yeganeh M, Rodriguez de Fonseca F, Raber J, Koob GF, and Weiss F. Increase of extracellular corticotropin releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. Journal of Neuroscience 15(8): 5439-5447, 1995.
   6. Weiss F, Lorang MT, Bloom FE,and Koob GF. Oral alcohol self-administration stimulates dopamine release in the nucleus accumbens; genetic and motivational determinants. Journal of Pharmacology and Experimental Therapeutics 267: 250-258, 1993.
   7. Hauger RL, Irwin MR, Lorang MT, Aguilera G, and Brown MR. High intracerebral levels of CRH result in CRH receptor down-regulation in the amygdala and neuroimmune desensitization. Brain Research 616: 283–292, 1993.
   8. Swerdlow NR, Koob GF, Cador M, Lorang MT, and Hauger RL.Pituitary-adrenal axis responses to acute amphetamine in the rat. Pharmacology, Biochemistry and Behavior 45: 629-637, 1993.
   9. Weiss F, Paulus MP, Lorang MT and Koob GF. Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. Journal of Neuroscience 12: 4372–4380, 1992.
   10. Weiss F, Markou A, Lorang MT, and Koob GF. Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited access self-administration. Brain Research 593: 314-318, 1992.
   11. Hauger RL, Lorang MT, Irwin M, and Aguilera G. CRF receptor regulation and sensitization of ACTH responses to acute ether stress during chronic intermittent immobilization stress. Brain Research 532: 34-40, 1990.
   12. Hauger RL, Millan M, Harwood JP, Lorang MT, Catt KJ, and Aguilera G. Receptors for corticotropin releasing factor in the pituitary and brain: regulatory effects of glucocorticoids, CRF, and stress. In Molecular Biology of Stress, pp 3- 17. UCLA Symposia in Molecular and Cellular Biology, New Series. Vol 97, 1989. Alan R. Liss, Publisher.
   13. Catherwood BD, Addison J, Chapman G, Contreras S, and Lorang MT. Growth of rat osteoblast-like cells in a lipid-enriched culture medium and regulation of function by parathyroid hormone and 1,25-dihydroxyvitamin D. Journal of Bone and Mineral Research 3: 431-438, 1988.
   14. Hauger RL, Millan MA, Lorang MT, Harwood JP, and Aguilera G. Corticotropin releasing factor receptors and pituitary adrenal responses during immobilization stress. Endocrinology 123: 396-405, 1988.
   15. Titus L, Rubin JE, Lorang MT, and Catherwood BD. Glucocorticoids and 1,25-dihydroxyvitamin D3 regulate parathyroid hormone stimulation of adenosine 3’,5’-monophosphate-dependent protein kinase in rat osteosarcoma cells. Endocrinology 123: 1526-1534, 1988.

Abstracts:

More than 40 abstracts have been published and presented.

References: